A Facile Reaction of Unactivated Imines with Telluronium Allylide. Highly Stereoselective Synthesis of Vinylaziridines
نویسندگان
چکیده
Supporting Information General methods. Infrared spectra were recorded on a Nicolet AVATAR-360 spectrometer. H NMR and C NMR spectra were recorded at Bruker AM-300 instruments. Low resolution mass spectra (m/z) were recorded on HP5989A. High-resolution mass spectra were recorded on Concept 1H or MALDI/DHB. Microanalyses were performed using a Elemantar Vario EL. All reaction flasks were dried by flame. And all reactions were carried out under argon unless otherwise noted. THF and toluene were dried by distilled over sodium-benzophenone ketyl prior to use. N-aryl imines and -amidoalkyl-p-tolyl sulfones were prepared according to literature methods.
منابع مشابه
Regio- and stereoselective synthesis of benzothiazolo-pyrimidinones via an NHC-catalyzed Mannich/lactamization domino reaction.
An NHC-catalyzed regio- and stereoselective Mannich/lactamization domino reaction of N-(benzothiazolyl)imines with α-chloroaldehydes has been developed. This new protocol provides a facile approach for the asymmetric synthesis of benzothiazolo-pyrimidinones and a pyrrolo[1,2-a]indolone in moderate to good yields (34-78%) and excellent stereoselectivities (87-99% ee, up to >20 : 1 d.r.).
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